September 25, 2023: The Panel on Opportunistic Infections in Adults and Adolescents (the Panel) updated the Guidelines for the Prevention and Treatment of Opportunistic Infections in Adults and Adolescents with HIV. Highlights from the updated sections are summarized below: 

Syphilis 

• Updated data on incidence.  
• Provided information on ocular syphilis.  
• Updated the discussion of diagnostic algorithms.  
• Provided information on doxycycline post-exposure prophylaxis for bacterial sexually transmitted infections.  
• Provided information on the availability of benzathine penicillin and procaine penicillin. 

Tables 4, 5, and 6 

• Updated to include medications used for the treatment of mpox. 

For a list of recent updates, please see What’s New in the Guidelines. To view or download the Guidelines for the Prevention and Treatment of Opportunistic Infections in Adults and Adolescents with HIV, go to the Clinicalinfo website. The guidelines tables and recommendations also can be downloaded as separate PDF files. 

Clinicalinfo welcomes your feedback on the latest revisions to the Guidelines for the Prevention and Treatment of Opportunistic Infections in Adults and Adolescents with HIV. Please send your comments with the subject line “Adult and Adolescent Opportunistic Infection Guidelines” to HIVinfo@NIH.gov by October 11, 2023.